abstract：:The term Unfit refers to older cancer patients not amenable with standard treatment and needing therefore a modified or attenuated treatment or also not deserving an active therapeutic approach. To determine whether an old patient is Unfit a Multidimensional Geriatric Evaluation is needed, but to spare time, shortened...

journal_title：Cancer treatment reviews

authors： Monfardini S

更新日期：2009-10-01 00:00:00

abstract：:Pancreatic cancer is a disease with a high mortality rate and short survival, as a result of the high incidence of metastatic disease at diagnosis, the fulminant clinical course and the lack of successful therapeutic strategies. The administration of chemotherapeutic agents for the treatment of advanced disease has fa...

journal_title：Cancer treatment reviews

authors： Pliarchopoulou K,Pectasides D

更新日期：2009-08-01 00:00:00

abstract：:The prognosis of advanced pancreatic adenocarcinoma is still poor nowadays. Gemcitabine in monotherapy (30-min infusion) has been the standard of treatment during the last decade, and many clinical trials have failed to demonstrate an improvement in overall survival (OS) with the addition of different drugs to gemcita...

journal_title：Cancer treatment reviews

authors： Rivera F,López-Tarruella S,Vega-Villegas ME,Salcedo M

更新日期：2009-06-01 00:00:00

abstract：:Pancreatic cancer retains a poor prognosis among the gastrointestinal cancers and remains a challenge in oncology. In 1997, gemcitabine became the standard of care in metastatic setting. In the last decades, despite a number of clinical trials assessing novel cytotoxic agents and cell signaling inhibitors, overall sur...

journal_title：Cancer treatment reviews

authors： El Maalouf G,Le Tourneau C,Batty GN,Faivre S,Raymond E

更新日期：2009-04-01 00:00:00

abstract：:Patients with malignant disease may need hormonal therapy as primary or adjuvant treatment or for palliation. Oestrogens usually decrease serum levels of total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C), increase high density lipoprotein cholesterol (HDL-C) concentration, but induce an elevation ...

journal_title：Cancer treatment reviews

authors： Filippatos TD,Liberopoulos EN,Pavlidis N,Elisaf MS,Mikhailidis DP

更新日期：2009-04-01 00:00:00

abstract：PURPOSE:To summarize and define the methodological quality of primary research findings obtained in exercise interventions, aimed at improving physical function or psychological well-being in patients treated for haematological malignancies. METHODS:Relevant trials were identified through a computerized Mesh-search in...

journal_title：Cancer treatment reviews

authors： Liu RD,Chinapaw MJ,Huijgens PC,van Mechelen W

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:We performed a systematic review and meta-analysis of randomised trials of neo-adjuvant hormone therapy (NHT) in localised and locally advanced prostate cancer to assess the effectiveness of this therapy. METHODS:We searched MEDLINE, The Cochrane Library, Science Citation Index, LILACS and SIGLE for randomi...

journal_title：Cancer treatment reviews

authors： Shelley MD,Kumar S,Wilt T,Staffurth J,Coles B,Mason MD

更新日期：2009-02-01 00:00:00

abstract：:Management of early stages non-small cell lung carcinoma has traditionally been surgery with radiation selected for medically inoperable patients. Recent emergence of stereotactic body radiation therapy allows for delivery of high radiation dose to the tumor while sparing normal lungs. This reviews compares loco-regio...

journal_title：Cancer treatment reviews

authors： Nguyen NP,Garland L,Welsh J,Hamilton R,Cohen D,Vinh-Hung V

更新日期：2008-12-01 00:00:00

abstract：:Glioblastoma is the most malignant and frequent primary brain tumour in adults. Current treatment remains insufficient as these tumours display a diffuse infiltrative growth pattern and tend to recur despite extensive debulking surgery followed by radio- and chemotherapy. The alkylating agents carmustine (1,3-bis-(2-c...

journal_title：Cancer treatment reviews

authors： Johannessen TC,Bjerkvig R,Tysnes BB

更新日期：2008-10-01 00:00:00

abstract：:Metastatic colorectal cancer (CRC) is most frequently seen in the liver. Resection of metastases remains the treatment of choice; however, the majority of patients are ineligible for surgery due to unfavorable location, size, or number of metastases; insufficient liver reserve; or extrahepatic disease. The activity of...

journal_title：Cancer treatment reviews

authors： Pozzo C,Barone C,Kemeny NE

更新日期：2008-06-01 00:00:00

abstract：:In the last ten years, the development of several novel targeted drugs and the refinement of state of the art technologies such as the genomics and proteomics and their introduction to clinical practice have revolutionized the management of patients affected by cancer. However, everyday practice points out several cli...

journal_title：Cancer treatment reviews

authors： Pantaleo MA,Nannini M,Maleddu A,Fanti S,Ambrosini V,Nanni C,Boschi S,Biasco G

更新日期：2008-04-01 00:00:00

abstract：:Adolescent patients with cancer reside in a "no-man's land" between the world of pediatric oncology and that of "adult" medical oncology. As compared to younger and older patients, adolescents and young adults are under-represented on clinical trials. This relative lack of participation in clinical protocols has been ...

journal_title：Cancer treatment reviews

authors： Ferrari A,Bleyer A

更新日期：2007-11-01 00:00:00

abstract：:Infertility is a common and distressing late-effect of cancer treatment. Whist sperm banking for post-pubertal males and embryo freezing for women (who are in a stable relationship at the time of treatment) are highly successful fertility preservation strategies, for females without a partner (including young and pre-...

journal_title：Cancer treatment reviews

authors： Pacey AA

更新日期：2007-11-01 00:00:00

abstract：:Prostate cancer (CaP) is one of the most common malignancies in men, with an increasing incidence. Despite significant advances in surgery, chemotherapy and radiotherapy to treat CaP, many patients unfortunately succumb to secondary disease (metastases). The invasive ability of tumour cells plays a key role in CaP met...

journal_title：Cancer treatment reviews

authors： Li Y,Cozzi PJ

更新日期：2007-10-01 00:00:00

abstract：:Arsenic is a semi-metal or metalloid with two biologically important oxidation states, As(III) and As(V). As(III), in particular, reacts with closely spaced protein thiols, forming stable cyclic dithioarsinite complexes in which both sulfur atoms are bound to arsenic. It is this reaction that is mostly responsible for...

journal_title：Cancer treatment reviews

authors： Dilda PJ,Hogg PJ

更新日期：2007-10-01 00:00:00

abstract：:Cardiac toxicity has been implicated as the primary reason for excess non-breast cancer mortality in early breast cancer radiotherapy studies. Refinements in radiotherapy techniques have allowed for a considerable reduction of this risk in the majority of breast cancer patients. Recent large population-based studies c...

journal_title：Cancer treatment reviews

authors： Senkus-Konefka E,Jassem J

更新日期：2007-10-01 00:00:00

abstract：:Six major randomized clinical trials evaluating the role of taxanes in the adjuvant setting of breast cancer have demonstrated significant improvements in terms of efficacy in favour of the taxane treatment arm. In all cases, different anthracycline-based regimens were used as the control arm. Nevertheless, many clini...

journal_title：Cancer treatment reviews

authors： Estévez LG,Muñoz M,Alvarez I,Fernández Y,García-Mata J,Ruiz-Borrego M,Tusquets I,Seguí MA,Rodríguez-Lescure A,Adrover E,Lluch A

更新日期：2007-08-01 00:00:00

abstract：:Oxaliplatin is widely regarded as being active in cisplatin-resistant cancer. We undertook a systematic review of the literature to identify, describe and critique the clinical and pre-clinical evidence for the use of oxaliplatin in patients with "cisplatin-resistant" cancer. We identified 25 pre-clinical cell models ...

journal_title：Cancer treatment reviews

authors： Stordal B,Pavlakis N,Davey R

更新日期：2007-06-01 00:00:00

abstract：BACKGROUND:Patients who are diagnosed with cancer want advice on how they may alter their diet or which diet supplements they should take to augment chemotherapy. METHODS:We conducted a review of the literature mostly from the last 15 years on the interaction between dietary constituents and antineoplastic therapy in ...

journal_title：Cancer treatment reviews

authors： D'Incalci M,Steward WP,Gescher AJ

更新日期：2007-05-01 00:00:00

abstract：BACKGROUND:Surgical bypass and endoscopic stents are available for palliative bypass of malignant distal biliary obstruction. AIM:Comparison of reported outcomes in randomized controlled trials (RCTs) which included surgery, endoscopic plastic stents or endoscopic metal stents in palliative relief of malignant distal ...

journal_title：Cancer treatment reviews

authors： Moss AC,Morris E,Leyden J,MacMathuna P

更新日期：2007-04-01 00:00:00

abstract：:The use of endocrine therapy is well established as a primary treatment for locally advanced breast cancer. However, despite the current popularity of neoadjuvant chemotherapy for operable tumours, there is relatively little published evidence for pre-operative endocrine therapy in operable disease, particularly outsi...

journal_title：Cancer treatment reviews

authors： Beresford MJ,Ravichandran D,Makris A

更新日期：2007-02-01 00:00:00

abstract：:Metastatic colorectal cancer remains a public-health issue on a global scale. With development of a new generation of cytotoxic agents, survival has improved for patients with metastatic disease. How to maximize the benefit of chemotherapy with acceptable toxicity remains incompletely answered. Hepatic resection can p...

journal_title：Cancer treatment reviews

authors： Saletti P,Cavalli F

更新日期：2006-11-01 00:00:00

abstract：:Solid tumours contain regions of hypoxia, which may be a prognostic indicator and determinant of malignant progression, metastatic development and chemoradio-resistance. The degree of intra-tumoural hypoxia has been shown to be positively correlated with the expression of the transcription factor hypoxia-inducible fac...

journal_title：Cancer treatment reviews

authors： O'Donnell JL,Joyce MR,Shannon AM,Harmey J,Geraghty J,Bouchier-Hayes D

更新日期：2006-10-01 00:00:00

abstract：:Biliary tract cancer is a quite rare disease; despite recent significant advances in imaging modalities, most of the patients have advanced disease at presentation thus making radical surgery not feasible. Many different chemotherapeutic regimens have been investigated in small uncontrolled studies, with generally dis...

journal_title：Cancer treatment reviews

authors： Berardi R,Scartozzi M,Freddari F,Squadroni M,Santinelli A,Bearzi I,Fabris G,Cascinu S

更新日期：2006-08-01 00:00:00

abstract：:Cancer patients with pain may not respond to increasing doses of opioids because they develop adverse effects before achieving an acceptable analgesia, or the analgesic response is poor, despite a rapid dose escalation. Opioid switching may significantly improve the balance between analgesia and adverse effects. We co...

journal_title：Cancer treatment reviews

authors： Mercadante S,Bruera E

更新日期：2006-06-01 00:00:00

abstract：BACKGROUND:The colony-stimulating factors (CSFs) are widely utilized to prevent neutropenic complications in both adults and children, but randomized controlled trials in the pediatric setting have reported varied results. A systematic review of the literature and meta-analysis were conducted to definitively assess the...

journal_title：Cancer treatment reviews

authors： Wittman B,Horan J,Lyman GH

更新日期：2006-06-01 00:00:00

abstract：:The HER2 oncogene encodes a transmembrane protein partially homologous to epidermal growth factor receptor. This oncogene has been studied mainly in breast cancer where it has prognostic, predictive and therapeutic target value. The expression of HER2 in epithelial ovarian cancer has been less studied. HER2 expression...

journal_title：Cancer treatment reviews

authors： Serrano-Olvera A,Dueñas-González A,Gallardo-Rincón D,Candelaria M,De la Garza-Salazar J

更新日期：2006-05-01 00:00:00

abstract：:Microtubule stabilization by chemotherapy is a powerful weapon in the war against cancer. Disruption of the mitotic spindle activates a number of signaling pathways, with consequences that may protect the cell or lead to its death via apoptosis. Taxol, the first microtubule stabilizing drug to be identified, has been ...

journal_title：Cancer treatment reviews

authors： Bergstralh DT,Ting JP

更新日期：2006-05-01 00:00:00

abstract：:Vinorelbine is a semi-synthetic vinca alkaloid that has been shown active in many tumour types and is currently registered for the treatment of advanced breast cancer (ABC) and non-small cell lung cancer (NSCLC). This agent has a generally favourable safety profile, and may be suitable for use in special populations s...

journal_title：Cancer treatment reviews

authors： Mano M

更新日期：2006-04-01 00:00:00

abstract：:Patients with advanced cancer often develop bone metastases that lead to significant skeletal morbidity and substantially reduced functionality and autonomy [Coleman RE, Rubens RD. Bone metastases. In: Clinical Oncology, 2nd edn. New York: Churchill Livingstone. 2004, p. 1091-128]. As current methods of diagnosing bon...

journal_title：Cancer treatment reviews

authors： Coleman RE

更新日期：2006-01-01 00:00:00

abstract：:Rituximab, a human/mouse chimeric anti-CD20 antibody, has become part of standard therapy for patients with CD20-expressing B-cell lymphoma, and is currently under investigation for other indications including autoimmune diseases, in particular rheumatoid arthritis (RA). Its characteristic tolerability profile was est...

journal_title：Cancer treatment reviews

authors： Kimby E

更新日期：2005-10-01 00:00:00

abstract：:Drug resistance is a major problem in the treatment of solid tumours. Based on a steep dose-response relationship for especially alkylating agents on tumour cell survival, high-dose chemotherapy was considered of interest for the treatment of solid tumours. Results of phase 1 and 2 studies with high-dose chemotherapy ...

journal_title：Cancer treatment reviews

authors： Nieboer P,de Vries EG,Mulder NH,van der Graaf WT

更新日期：2005-05-01 00:00:00

abstract：PURPOSE:To evaluate the existing evidence regarding the long-term risk of cardiovascular disease (CVD) after radiotherapy for childhood cancer. PATIENTS AND METHODS:MEDLINE and EMBASE were searched for articles reporting on radiation-induced CVD after childhood cancer published between 1966 and October 2002. Informati...

journal_title：Cancer treatment reviews

authors： van der Pal HJ,van Dalen EC,Kremer LC,Bakker PJ,van Leeuwen FE

更新日期：2005-05-01 00:00:00

abstract：:The existence of branchiogenic carcinoma remains controversial. According to some authors, this malignancy is more conceptual than a true clinicopathologic entity. The originally proposed diagnostic criteria of branchiogenic carcinoma have been subsequently challenged. Many reports regarding primary branchiogenic carc...

journal_title：Cancer treatment reviews

authors： Jereczek-Fossa BA,Casadio C,Jassem J,Luzzatto F,Viale G,Bruschini R,Chiesa F,Orecchia R

更新日期：2005-04-01 00:00:00

abstract：:Despite improvements in the management of patients with early breast cancer, the prognosis for women with locally advanced breast cancer (LABC) remains poor. The potential goals of neoadjuvant treatment for this disease include down-sizing tumours to allow breast conservation as well as the possibility of improving su...

journal_title：Cancer treatment reviews

authors： Freedman OC,Verma S,Clemons MJ

更新日期：2005-02-01 00:00:00

abstract：:At diagnosis, 25-40% of patients with small cell lung cancer (SCLC) are 70 years of age or older, and many of them have been undertreated because of fear of excessive toxicity associated with chemotherapy. Papers retrieved by a Medline search using the key words "elderly or older" and "small cell lung cancer" and by a...

journal_title：Cancer treatment reviews

authors： Sekine I,Yamamoto N,Kunitoh H,Ohe Y,Tamura T,Kodama T,Saijo N

更新日期：2004-06-01 00:00:00

abstract：GOALS OF THE WORK:Malignancy produces a state of physiologic stress that is characterized by a relative deficiency of glutamine, a condition that is further exacerbated by the effects of cancer treatment. Glutamine deficiency may impact on normal tissue tolerance to antitumor treatment, and may lead to dose reductions ...

journal_title：Cancer treatment reviews

authors： Savarese DM,Savy G,Vahdat L,Wischmeyer PE,Corey B

更新日期：2003-12-01 00:00:00

abstract：:Despite their particular functional consequences, radiotherapy-induced ear injuries remain under-evaluated and under-reported. These reactions may have acute or late character, may affect all structures of the hearing organ, and result in conductive, sensorineural or mixed hearing loss. Up to 40% of patients have acut...

journal_title：Cancer treatment reviews

authors： Jereczek-Fossa BA,Zarowski A,Milani F,Orecchia R

更新日期：2003-10-01 00:00:00

abstract：:Tissue hypoxia occurs where there is an imbalance between oxygen supply and consumption. Hypoxia occurs in solid tumours as a result of an inadequate supply of oxygen, due to exponential cellular proliferation and an inefficient vascular supply. It is an adverse prognostic indicator in cancer as it is associated with ...

journal_title：Cancer treatment reviews

authors： Shannon AM,Bouchier-Hayes DJ,Condron CM,Toomey D

更新日期：2003-08-01 00:00:00

abstract：:Prostate cancer is a significant cause of morbidity and mortality in the United States and Europe. The natural ageing of the population as well as the continued and widespread use of diagnostic tests such as prostate specific antigen (PSA), has led to an increase in the numbers of men diagnosed with localised prostate...

journal_title：Cancer treatment reviews

authors： Linton KD,Hamdy FC

更新日期：2003-06-01 00:00:00